Understanding Metastatic Lung Cancer

Understanding Metastatic Lung Cancer

Most times, lung cancer starts in the lungs as a small tumor. But, it can spread to other body parts and is known as stage 4 or metastatic lung cancer. The spread occurs via the bloodstream and the lymph nodes. Treatment options for metastatic lung cancer differ from that of cancer in its initial stages. It can also cause fluid retention in and around the lungs. This fluid often shows the presence of cancer cells.

What are the stages of lung cancer?
Lung cancer can be divided into 6 stages.
Occult Stage:  This is also called hidden cancer, as the cancer cells are only present in mucus and cannot be seen on imaging tests.
Stage 0:  At this stage, the tumor is small and hasn’t managed to invade the deeper layers of lung tissue.
Stage 1:  Cancer is present in lung tissues.
Stage 2:  Cancer spreads to the lymph nodes surrounding the lungs.
Stage 3:  Cancer cells have further invaded the lymph nodes and the chest.
Stage 4:  Stage 4, or metastatic lung cancer, is when the cancer cells spread to different body parts. Common organs to be affected by metastatic lung cancer include the liver, bones, and brain.

What are the symptoms of metastatic lung cancer?
The type and severity of symptoms present in a patient often indicate metastatic lung cancer. Some of these symptoms may be present in earlier stages of cancer but grow severe as the condition progresses. These symptoms include:
A persistent cough that worsens with time
Coughing up blood or hemoptysis
Chest pain that can worsen with cough and, in some cases, even with deep breathing
Wheezing
Shortness of breath
Increased frequency of lung infections such as pneumonia and bronchitis
Hoarse voice
Poor appetite
Sudden and unintentional loss of body mass
Weakness and fatigue

These are all symptoms associated with lung health. Some other symptoms that can be present depending on where cancer has metastasized are as follows:
Swollen lymph nodes of the neck
In case of spread to the liver, the patient may also show the presence of jaundice
Pain in bones in the hips or the back
Weakness
Numbness of limbs
Seizures if cancer spreads to the brain
Issues with balance

The mere presence of these symptoms is not a confirmation of cancer. Therefore, getting the necessary tests done and consulting a specialist for accurate guidance is important. Some of these symptoms might also indicate the presence of a less severe condition that might be easily treatable.

How is metastatic lung cancer diagnosed?
Diagnosis generally involves blood tests, imaging, and biopsy tests to detect the type of cancer. The doctor determines the exact tests one needs to undergo based on the symptoms. Some standard testing methods used in the diagnosis of metastatic or stage 4 lung cancer are:

MRI:  Magnetic resonance imaging provides detailed images of the inside of the body. It allows doctors to get a better look at all the organs in the body and get a clearer picture of the extent of cancer spread. Getting an MRI is important since it helps determine a treatment plan for metastatic cancer.

CT scan:  Computerized tomography is an imaging test just like MRI. It is used to determine whether cancer has spread to the brain, adrenal glands, lymph nodes, liver, and other organs.

PET scans:  A positron emission tomography test is done to detect cancer cells in the body. The tests highlight carcinogenic cells and make it easier to find their location. Patients are injected with a radioactive solution before taking this test. This solution settles cancer cells throughout the body and helps obtain clearer results.

Bone scan:  Bone scans are performed to check the presence of carcinogenic cells in the bone. This test, too, requires patients to be injected with a radioactive solution. The solution highlights cancer cells in the bones, and unlike a PET scan, it only concentrates on cancer in the bones.

Biopsy:  Irrespective of the other preliminary tests conducted during the diagnosis process, a cancer diagnosis is not confirmed without testing the tissue sample of the tumor. The diagnosis is confirmed only after the biopsy results come in positive. A small sample of cells or tissue is collected and passed on to a pathologist, who then tests the sample microscopically for the presence of cancerous activity.

How is metastatic lung cancer treated?
Once cancer has been diagnosed, the treatment plans depend on the stage of cancer. It might involve surgery, radiation therapy, targeted therapy, and even a combination of two or more treatment methods. The exact formation of a treatment plan might require the involvement of a team of oncologists. When cancer has already spread, treatment is aimed primarily at preserving the patient’s quality of life while gaining control over symptoms and prolonging life expectancy.

Options like radiation therapy target some symptoms and manage them better. Since the therapy can be used only in targeted areas, it is a safe option. Some common instances of radiation therapy include metastasis in bones and the brain. However, in the case of lung cancer, the biggest reason for its use remains symptom management.

Another treatment option that can be used in patients with metastatic lung cancer includes chemotherapy. It can help attack cancer cells all over the body at the same time. These targeted therapy treatments have helped improve the treatment outcome and increased the odds of survival of people with stage 4 non-small cell lung cancer.

The fluid buildup is also a symptom in people with metastatic lung cancer. In this case, doctors can help drain the fluid and relieve pressure on the lungs.

Coming up with a treatment plan is based on factors such as the patient’s current condition, age, and the organs to which cancer has spread. It might involve the use of combination therapies, oral treatments, and some injectables. However, it is important to remember that all treatment methods are meant to help in symptom management at this stage.

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Known Signs of Hemophilia and Anemia

Bleeding disorders refer to a group of conditions like hemophilia or anemia that interfere with normal blood functions in the body. Hemophilia affects the ability of the blood cells to clot naturally, while anemia lowers hemoglobin count in the red blood cells. These conditions exhibit a unique set of symptoms that can be identified. Early diagnosis helps doctors form a viable healthcare plan. So, it pays to know and identify the following symptoms. Hemophilia and Anemia: Understanding the difference Both conditions are common bleeding disorders. However, anemia & hemophilia signs are distinctly different from each other when it comes to the disease progression. The latter is a genetic disorder that affects the red blood cell’s ability to clot and close wounds. Certain clotting factors in the blood bind with the red blood cells to prevent uncontrolled bleeding. Anemia is a condition where the body lacks sufficient healthy red blood cells in the first place. Also, a low hemoglobin count affects the red blood cell’s ability to carry oxygen to vital organs and extremities via the circulatory system. Genetic mutation triggers most known types of hemophilia, while certain nutritional deficiencies in the body trigger common forms of anemia. Symptoms of hemophilia The absence of essential clotting factors in the blood can trigger a variety of noticeable and unusual symptoms. Uncontrolled bleeding Bleeding is one of the primary symptoms of hemophilia. It can happen under the skin or in the joints. As the red blood cells are unable to bind and clot, this pool of blood can trigger swelling, pain, and tightness in the joints. This symptom is most commonly noticeable in the knees, elbows, and ankles. Blood collecting under the skin can lead to buildups under the muscle and soft tissue to cause more painful bruising. This symptom is called hematoma in medical terminology. Frequent nosebleeds When the bleeding is triggered externally, it can result in frequent nosebleeds that can be difficult to stop. Note that external environmental factors and physical injuries generally cause nosebleeds. So, any unexplained bleeding could indicate a developing condition. Bleeding caused due to cuts, bruises, and vaccinations Lack of essential clotting factor VIII can trigger bleeding from the lightest of impacts, cuts, bruises, or even after losing a tooth. Some people experience sudden bleeding after taking a vaccination. This could be the body’s reaction to producing antibodies, but the strain could be too much to bear, resulting in bleeding from the extremities. Blood in urine or stool Excess blood in the urine or stool is a clear sign of disease progression. The urine and stools appear dark red or even blackish due to the presence of red blood cells mixed with the excreta. Immediate medical assistance is advisable for visual symptoms. Bleeding in infants Complicated pregnancies can be physically taxing for both the mother and the child leading to possible symptoms of hemophilia at birth. But in some rare cases, infants may experience internal bleeding in the head. Symptoms of anemia The most common types of anemia, including iron deficiency anemia and vitamin deficiency anemia, develop due to the lack of nutrients in the body. Therefore, anemia exhibits more physically taxing symptoms as the condition worsens. Tiredness Increased fatigue and weakness for no apparent reason is one of the main indicators of nutritional deficiencies. An unexplained decrease in overall stamina with no physical exertion or any activity during the day could mean low iron in the blood. Without iron, the body cannot produce enough red blood cells. And low hemoglobin means not enough oxygen is being circulated around vital organs in the body, thus resulting in fatigue induced by low energy levels. Respiratory symptoms Experiencing shortness of breath, chest pains, and even noticing an irregular heartbeat could indicate a possible anemic condition. An iron deficiency lowers hemoglobin count, and this means not enough oxygen is being circulated by the blood. Low hemoglobin affects the breathing rate as the body struggles to extract more oxygen resulting in shortness of breath. The heart must also put in extra efforts to pump the low hemoglobin blood forcefully, thus resulting in irregular heartbeats. Doctors refer to this condition as heart palpitations. These symptoms can also induce chest pains due to the sheer stress being put on the organ. Pale skin and damaged hair Skin and hair symptoms are visible indicators of a developing anemia condition. An iron deficiency results in low red blood cell production and indirectly affects the shade of the skin. Pale skin is noticeably visible around the face, gums, lower lips, lower eyelids, and even on the nails. This symptom is more visually obvious among people who flaunt a lighter skin tone. Also, hair thinning, hair fall, and a damaged scalp is a clear sign of iron deficiency. Treatment options Note that anemia & hemophilia signs never overlap. Once the primary indicators are confirmed, doctors quickly suggest blood tests to identify the leading causes or triggers. Knowing the differences can help with prompt diagnosis even though both the conditions are bleeding disorders. It is even possible to recover from common forms of anemia within 2 to 3 months. Hemophilia is a more serious bleeding disorder that is treated by introducing the missing clotting factors. Doctors also suggest prescriptions that help stimulate the body to release more clotting factors. However, a transfusion offers more promising results for moderate to severe progression. Effective preventive measures and home remedies can help lower the risk of bleeding. These conditions cannot be completely cured. But it is possible to improve the quality of life by incorporating healthy lifestyle habits. Prescriptions and treatments only help slow down the disease progression.

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Multiple Myeloma – Uncommon Signs and Key Facts

Multiple myeloma is a type of cancer that develops in the plasma cells. Healthy plasma helps the body fight infections by making antibodies, but for those affected with multiple myeloma, this plasma in the bone marrow is crowded out by cancerous cells. These cells produce abnormal proteins that can lead to complications. About 100,000 people in the country seem to be affected by this rare form of blood cancer. Uncommon signs The progress of multiple myeloma leads to the development of other conditions like amyloidosis, hypercalcemia, and anemia. This can lead to the following lesser-known multiple myeloma signs: Amyloidosis: This causes a buildup of proteins in the body that can injure organs and interfere with their functioning. In addition to the common symptoms of myeloma, amyloidosis also includes purple spots on the skin, swollen tongue and other issues with swelling, numbness or tingling sensation in the limbs, painful joints, diarrhea, clay-colored stools, or other digestive problems. Hypercalcemia: Damage to the bone structure from myeloma can lead to the release of excessive amounts of calcium in the blood, also known as hypercalcemia. This can exhibit signs like nausea, vomiting, loss of appetite, constipation and other digestive issues, twitching of muscles, or restlessness. Anemia: Overpopulation of cancerous cells in the bone marrow can crowd out other healthy blood stem cells that produce red blood cells, leading to anemia or a low red blood cell count. Symptoms of anemia include easy bruising or bleeding, cognitive issues, such as trouble thinking or getting easily confused, and a feeling one's limbs are weak or easily fatigued. Kidney failure: Amyloidosis, hypercalcemia, and excess M-protein and antibodies released by growing plasma tumor cells can damage organs like the kidneys, nerves, heart, muscles, and the digestive tract. Multiple myeloma can lead to kidney failure and damaged peripheral nerves in the limbs. Signs of kidney failure are high blood pressure, fluid retention, swelling of the legs, feet, or ankles, headaches, itching, muscle cramps, and stiffness of fluid in the joints. Common signs Initial signs of multiple myeloma may be mild manifestations or even undetectable. This precursor stage is known as smoldering multiple myeloma (SMM) and needs to be monitored closely. The symptoms worsen with the growth of abnormal cancer cells in the body. These cells crowd out the healthy plasma cells affecting the bone structure and releasing antibodies, M-protein, and other proteins that thicken the blood. While multiple myeloma signs can differ for every person, common symptoms are: Pain in the bones of the back or the ribs: Bone damage associated with MM usually occurs around the rib cage, spine, and pelvis. This increases the risk of spinal cord compression, which can lead to pain, numbness, and weakness in the body and needs to be treated immediately. Bones that fracture easily Fatigue and weakness Shortness of breath Dizziness Frequent infections and fevers Frequent need to urinate Extreme thirst Weakness or numbness in the legs Mental fogginess or confusion Loss of appetite Constipation Those experiencing one or more multiple myeloma signs must consult a doctor immediately. Trained professionals can help create personalized treatment plans based on the type, stage, and personal health history of each individual. Risk factors Factors that can increase a person’s likelihood of developing multiple myeloma are: Age: The risk of multiple myeloma increases with age, with most diagnoses in the mid-60s age group. Sex: Men are more likely to develop the disease than women. Ethnicity: People of African descent are more likely to develop multiple myeloma than others. Family history: People with an immediate family history of multiple myeloma are at an increased risk of developing the disease. Personal history: Multiple myeloma often starts as monoclonal gammopathy of undetermined significance (MGUS). People with this condition are at a greater risk of developing the disease. Complications Apart from kidney failure and anemia, complications caused by multiple myeloma are: Frequent infections: The growth of cancerous cells inhibits the body’s ability to fight infections. Bone problems: Multiple myeloma can affect the bones, leading to bone pain, thinning bones, and broken bones. Diagnosis Multiple myeloma is diagnosed after a thorough clinical examination, an inspection of one’s detailed patient history, and various specialized tests. The most commonly used tests are: Bone marrow aspiration and biopsy: This involves the removal and examination of a small sample of the bone marrow. Blood Tests: These are meant to detect low levels of red and white blood cells in the body. Imaging tests: Magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) scans can help detect any characteristic changes in the bones. Electrophoresis: This test uses electric currents to detect levels of M-protein in the blood or urine. Treatment Those with SMM may not require treatment right away. With the progress of the disease, the following standard treatment options may be recommended: Targeted therapy: Targeted treatments focus on specific weaknesses within cancer cells to block abnormalities and kill these cells. Immunotherapy: Immunotherapy interferes with the body’s immune system to fight cancer. Chemotherapy: Chemotherapy uses antidotes to kill fast-growing cancer cells. High doses of chemotherapy are used before a bone marrow transplant. Bone marrow transplant: For those with advanced multiple myeloma, a bone marrow transplant may be recommended to replace diseased bone marrow with healthy bone marrow. Radiation therapy: Radiation therapy involves the use of high-powered energy beams such as X-rays and protons to kill cancer cells. It may be used to shrink myeloma cells in a specific area. Further, certain prescription treatment options can regulate the immune system to control inflammation in the body. In addition to traditional therapies, research is being conducted to come up with several new treatment options. One should consult a doctor to learn about access to these clinical trials.

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