Liver Cancer – Symptoms, Causes, Diagnosis, and Management

The liver is located in the upper right portion of the abdomen, beneath the diaphragm and above the stomach. It removes toxins from the blood, maintains healthy blood sugar levels, and regulates blood clotting while carrying out other critical bodily functions. Some people develop certain types of cancer in the liver cells. Liver cancer affects more than 800,000 people globally and must be identified earliest possible to avoid or manage severe health complications.
Symptoms
The signs of liver cancer may not show up in the early stages. However, as the conditions progress, one may notice symptoms including nausea, vomiting, loss of appetite, weakness, fatigue, abdomen swelling, jaundice, chalky, white stools, and itching. Other symptoms that may affect one’s digestion include a lump in stomach areas and indigestion. Moreover, some liver types of liver cancers may produce hormones that affect other organs. They may result in symptoms such as –
- Heightened cholesterol levels
- Excessive blood calcium levels (hypercalcemia) lead to confusion, constipation, and muscle problems.
- Enlargement of the breast (gynecomastia) or shrinkage of testicles in men
- High levels of red blood cells (erythrocytosis) may make someone look red and flushed
- Low blood sugar levels (hypoglycemia) may lead to fatigue and fainting
Causes
The source of liver cancer differs between persons. Some people may develop the disease even if there are no underlying health conditions. So the precise cause of liver cancer is yet to be determined. However, other risk factors may increase the risk of developing liver cancer.
Chronic HBV or HCV
Chronic infection with the hepatitis B virus (HBV) or hepatitis C virus (HCV) puts one at a greater risk of developing the condition. According to estimates, nearly 65% of liver cancer cases are linked to these infections.
Cirrhosis
It is a progressive and irreversible condition that leads to scarring on the tissue forming in the liver. The phenomenon also increases the risk of developing liver cancer.
Diabetes
People with diabetes are at a bigger risk of developing liver cancer than those who do not have the complication.
Aflatoxin exposure
These are toxins produced by fungi that grow on poorly stored crops, including grains and nuts. When individuals eat this contaminated food, it can increase cancer risk.
Diagnosis
Healthcare experts may conduct a series of tests to determine if an individual has liver cancer. One diagnostic method includes conducting blood tests to identify abnormalities in one’s liver function. Imaging tests like ultrasounds, CT scans, and MRIs may also be required to check for liver cancer. Furthermore, when test results are inconclusive, a healthcare expert may remove a sample of the liver tissue to test it in the laboratory. This technique, known as liver biopsy, involves introducing a needle to the skin and into the liver to extract a tissue sample. The sample is then observed under a microscope to check for cancerous cells. One should also bear in mind that a liver biopsy may lead to side effects like bruising, infection, and bleeding.
Treatment
Once liver cancer is detected, the healthcare expert will suggest certain treatment options to manage the liver cancer, including surgery, chemotherapy, radiotherapy, palliative care, and thermal ablation.
Surgery
Various surgery options are usually considered for the treatment of liver cancer. One method is to conduct surgery to remove the affected region of the organ and a small portion of healthy liver tissue surrounding it. However, this procedure is conducted if the tumor is small and the liver still functions well. The location of cancer cells and the patient’s overall health are also considered before the surgery. Another method involves liver transplant surgery. Here the damaged liver is extracted and replaced with a healthy one from a donor. However, this option is suggested for a small percentage of individuals with early-stage liver cancer.
Chemotherapy
In chemotherapy, the healthcare expert will use prescriptions to eliminate quickly growing cancerous cells. For chemotherapy to be effective, it must be administered through a vein in the arm or taken as a prescription. Sometimes both methods might help manage the disease. Chemotherapy is also recommended for advanced stages of liver cancer.
Radiotherapy
This method uses a type of radiotherapy known as selective internal radiation therapy (SIRT) to help tackle liver cancer. Radioactive beads are introduced into the liver’s blood supply to prevent cancer cells from growing. The treatment is suitable for adults with a functional liver that is not too damaged. Radiotherapy is also indicated for use when the tumor cannot be removed with surgery.
Thermal ablation
In thermal ablation, electric currents are used to heat and destroy cancerous cells. The doctor uses an imaging test such as ultrasound as a guide during this method. Next, one or more thin needles are introduced into tiny incisions in the abdomen. Once the needles approach the tumor, they are heated with the current and eliminated.
Palliative care
This option involves receiving care from specialists who work with the patient, their family, and doctors to offer additional support with ongoing treatments. The method helps one relieve pain and other symptoms caused by severe conditions. Someone who receives palliative care to complement treatment options like chemotherapy, radiation therapy, or surgery may find improvements in their condition.
Coping and support
Receiving a diagnosis of liver cancer may affect one’s overall mental health, So apart from the treatments, one should also learn how to live with the health complication. Learning about liver cancer, its symptoms, and available treatments is one way to help patients decide. One can also ask friends and family members to help them with daily tasks. One could ask them to take care of the house, offer emotional support, and also help with trips for treatments like chemotherapy. Joining a support group is another way to live with the symptoms of liver cancer. Here, people with similar complications speak about their conditions, experiences, hopes, and fears and suggest ways to manage them.